They finally found a solution in Adobe's Acrobat software. Using the forms capabilites they have been able to develop a usable submission form and process which is truely platform neutral. The various federal agencies are now converting their PureEdge forms over to PDF forms. This may take some time though so keep an eye on what forms are available for your funding opportunity. As of January 1, 2009 NIH had sucessfully transitioned to the PDF forms. NSF completed conversion to PDF forms on March 1, 2009.
UPDATE, As of now ALL NIH grant submissions MUST be submitted electronically using the PDF forms (except for a select few programs). You can use either Acrobat Reader/Pro versions 8.1.6 or 9.2 to complete and save for submission your funding opportunity forms.