They finally found a solution in Adobe's Acrobat software. Using the forms capabilites they have been able to develop a usable submission form and process which is truely platform neutral. The various federal agencies are now converting their PureEdge forms over to PDF forms. This may take some time though so keep an eye on what forms are available for your funding opportunity. As of Spring 2008, 11 of 26 federal agencies had sucessfully transitioned to the PDF forms. The rest have a deadline of September 30, 2008. Both NIH and NSF have as yet to make the transition. Grants.gov has certified that both Acrobat Reader versions 8.1.2 and 9, as well as Acrobat Pro, will allow one to fully fill out and submit their new PDF forms. Note that this is the only option for filling out and submitting application packages for those people running Microsoft Windows VISTA.
UPDATE, July 16, 2008: In today's quarterly webinar it was mentioned that NIH and NSF have been given until December 2008 to complete the move to PDF forms. December 31, 2008 will be the last day that Pure Edge forms will be accepted for grant submission.