Therapeutic Efficacy Models - Antibacterial
UNTHSC Pre-Clinical Services currently offers the following protocols. Additional protocols can be developed and validated to meet the individual requirements of the sponsor.
Mouse Acute Lethal Infection (septicemia)
ED50 determinations for experimental molecules against infections with both gram-positive and gram-negative pathogens.
Mouse Subcutaneous Abscess
A chronic skin infection model involving either Staphylococcal (MRSA / MRSE), Streptococcal (pyogenes) or Pseudomonas aeruginosa bacterial isolates.
Mouse Superficial Skin Infection Model
A superficial skin infection model for the assessment of topical applications involving either Staphylococcus aureus or Streptococcus pyogenes infections.
Mouse Biofilm Catheter Implant
Model of device-related biofilm infection using subcutaneous S. aureus infected teflon catheter implants.
Mouse Lung Infection
Murine lung infections with S. pneumoniae, K. pneumoniae, A. baumannii and P. aeruginosa using survival (multiple dose regimen) or lung CFU (single dose) as measured endpoints.
Rat Central Venous Catheter Infection
Biofilm-like infection of an intravascular indwelling jugular catheter with S. aureus.
Granuloma Pouch
Infected pouch model for the simultaneous determination of penetration (levels) and efficacy (CFU counts) of administered agents in the rat or mouse.
Helicobacter pylori Gastritis (mouse)
Gastric infection model using H. pylori SS1 strain with efficacy measured as CFU log reduction / relapse.
Hamster C. difficile Infection
Experimental CDAD model for the evaluation of survival / relapse, GI pharmacokinetics and Tox A/B detection utilizing both susceptible and BI/NAP1 clinical isolates.
Neutropenic Thigh Infection Model
Determination of the Pharmacokinetic / Pharmacodynamic indices as related to the efficacy of an antimicrobial agent.
Mouse Urinary Tract Infection
Ascending pyelonephritis model using uropathogenic E. coli bacterial isolate with enumeration of the bacterial infection in kidneys, bladder and urine.
Rat Intra-abdominal Abscess Model
Mixed intra-abdominal infection with E. coli and B. fragilis
Rat Infective Endocarditis Model
S. aureus, Enterococcus
Antifungal Models
Systemic candidiasis
In Development
Diabetic mouse UTI model with Pseudomonas, murine superficial skin infection with Acinetobacter and Pseudomonas, murine pneumonia model with H. influenzae.
Additional Protocols / Procedures
Protocols of interest can be developed for sponsor as required.
