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Research Interests
The overall goal of the research program in Dr. Koulen's laboratory is to understand the function of synaptic proteins and intracellular signaling proteins in order to define causes and potential treatments of diseases affecting the nervous system. The current research focus is on intracellular calcium channels. These proteins contribute critically to several cellular functions including gene regulation, cell growth and differentiation, nerve cell function, cell motility and contraction. Intracellular calcium channels and their associated proteins are investigated using electron microscopy, immunocytochemistry, optical imaging of intracellular calcium concentrations, confocal laser scanning microscopy, and electrophysiology. Defining the changes in protein function will help identifying novel pharmacological targets for neuronal pathophysiology. The ultimate goal of the research efforts is the determination of underlying mechanisms of action and development of pharmacological and molecular biological treatments for disorders of the renal and visual system, and for cognitive decline during aging and Alzheimer’s disease.
Hot Links
Lab Members Page
Research Support:
http://www.nei.nih.gov/
http://www.nia.nih.gov/
http://www.arpatp.com/
http://www.pkdcure.org/
http://www.alz.org
http://www.grassfoundation.org/fellowships/grass_fellowship/former_fellows/lists/form_fellows_alph.html
http://www.narsad.org
Research Topics and Collaborators:
http://www.studienstiftung.de/
http://www.ku.edu/~micro/buechner.html
http://www.signaling-gateway.org
News and Events
Koulen speaks at center opening
Dr. Peter Koulen gave the keynote address at the grand opening of the Sunrise Assisted Living community of Fort Worth on June 7. The new community provides state-of-the-art assisted living and specializes in Alzheimer's and memory loss care. In his address Dr. Koulen, member of UNTHSC's Institute for Aging and Alzheimer's Disease Research and director of the North Texas Eye Institute, emphasized how the research and clinical facilities at the Health Science Center can benefit senior living facilities like this one. Also in attendance were Fort Worth City Councilman Chuck Silcox, representatives of Sunrise Senior Living, area health care professionals and future residents of the community and their families.
http://www.hsc.unt.edu/news/newsrelease.cfm?ID=197
http://www.hsc.unt.edu/news/newsrelease.cfm?ID=302
http://www.americanheart.org/presenter.jhtml?identifier=438
http://www.fwbusinesspress.com/display.php?id=3209&search=Koulen http://www.fwbusinesspress.com/display.php?id=3271&search=Koulen http://www.hsc.unt.edu/news/newsrelease.cfm?ID=527
Book Chapter
Planar Lipid Bilayers (BLMs) and their Applications
Edited by HT Tien and A. Ottova
(Elsevier Science, Amsterdam, New York, 2003) http://www.msu.edu/user/ottova/planar_lipid_bilayers.html
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