UNTHSC Pre-Clinical Services currently offers the following procedures and tests. Additional procedures can be developed and validated to meet the individual requirements of the sponsor.

Pharmacokinetics (IV, IP, SC, IM, PO)

Pharmacokinetics - Mouse, Rat, Rabbit, Guinea pig, Hamster and Dog

Single and/or multiple-dose studies.

Dose escalation pharmacokinetics.

Calculation of pharmacokinetic parameters.

Rat Disposition Studies

Levels of parent and/or metabolites in plasma, bile, urine, feces.

Preliminary Toxicology

Maximum Tolerated Dose (MTD)

Tolerability following IV, IP, SC, IM or PO administration.

Species: mouse and rat.

Repeat Dose Tolerability

Survival / observational endpoints.

Bioanalytical / Analytical

Plasma, Urine, Bile or Tissue Level Analysis

Analysis of biological fluids and tissues using LCMS or HPLC techniques.

Compound Stability

Stability of test compound in plasma, serum, microsomes (multiple species) and chemical (pH, other).