Advanced Mass Spectrometry and Proteomics Laboratory
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Mass Spectrometry-Protein Characterization & Proteomics
Expression Profiling and Proteome Characterization
Proteomic Analysis of Mouse Brain Microsomes: Identification and Bioinformatic. Characterization of Endoplasmic Reticulum Proteins in the Mammalian Central Nervous System. J Proteome Res.2008 March;7(3):1046-54. Stevens SM Jr, Duncan RS, Koulen P, Prokai L.
Effect of chronic morphine exposure on the synaptic
plasma-membrane subproteome of rats: a quantitative protein profiling study
based on isotope-coded affinity tags
and liquid chromatography/mass
spectrometry. J
Mass Spectrom.2005 Feb;40(2):169-75. Prokai L,
Zharikova AD, Stevens SM Jr.
Proteomic analysis of the synaptic plasma membrane fraction isolated from rat forebrain. Brain Res Mol Brain Res.2003 Oct 7;117(2):116-28. Stevens SM Jr, Zharikova AD, Prokai L.
Posttranslational Modifications
Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation. Anal Chem.2009 Jan;81(2):782-9. Rauniyar N, Stevens SM, Prokai-Tatrai K, Prokai L.
Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics. Mol Cell Proteomics.2008 Dec;7(12):2442-51. Stevens SM, Prokai-Tatrai K, Prokai L.
Mass spectrometry-based survey of age-associated protein carbonylation in rat brain mitochondria. J Mass Spectrom.2007 Dec;42(12):1583-9. Prokai L, Yan LJ, Vera-Serrano JL, Stevens SM, Forster MJ.
Fourier transform ion cyclotron resonance mass spectrometry of covalent adducts of proteins and 4-hydroxy-2-nonenal, a reactive end-product of lipid peroxidation. Anal Bioanal Chem.2007 Nov;389(5):1421-8. Rauniyar N, Stevens SM Jr, Prokai L.
Rapid characterization of covalent modifications to rat brain mitochondrial proteins after ex vivo exposure to 4-hydroxy-2-nonenal by liquid chromatography-tandem mass spectrometry using data-dependent and neutral loss-driven MS^3 acquisition. J Mass Spectrom.2007 Dec;42(12):1599-605. Stevens SM Jr, Rauniyar N, Prokai L.
De Novo Protein SequencingDe novo sequencing of a 21-kDa cytochrome c4 from Thiocapsa roseopersicina bynanoelectrospray ionization ion-trap and Fourier-transformion-cyclotronresonance mass spectrometry. J Mass Spectrom.2007 Dec;42(12):1569-82. Branca RM, Bodó G, Bagyinka C, Prokai L.
LC/MS: Pharmacokinetics & Drug Distribution
Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium. J Med Chem.2004 Nov 18;47(24):6025-33. Prokai L, Prokai-Tatrai K, Zharikova AD, Nguyen V, Perjesi P, Stevens SM Jr.
Integration of mass spectrometry into early-phase discovery and development of central nervous system agents. J Mass Spectrom.2001 Nov;36(11):1211-9. Prokai L, Zharikova AD, Janáky T, Li X, Braddy AC, Perjesi P, Matveeva L, Powell DH, Prokai-Tatrai K.
Exploratory pharmacokinetics and brain distribution study of a neuropeptide FF antagonist by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry. Rapid Commun Mass Spectrom.2000;14(24):2412-8. Prokai L, Zharikova AD, Janáky T, Prokai-Tatrai K.
Contact
information:
Department of Molecular Biology and Immunology
University of North
Texas Health Science Center
3500 Camp Bowie Blvd
Ft. Worth, TX 76107
Tel: 817.735.0619,
817.735.0629, Fax: 817.735.2118
E-mail: lprokai@hsc.unt.edu
Webpage:http://www.hsc.unt.edu/prokai/