Translational Research

• The discovery and development of novel estrogen-based neuroprotectants for the treatment of Alzheimer’s disease and other age-related disorders
• Assessment of 17 alpha-estradiol for longevity and vigor during aging
• Assessment of the uses of methylene blue for treatment of a variety of neurodegenerative diseases
• The assessment of dietary intervention on stroke, Alzheimer’s disease and other neurodegenerative conditions

Core translational Laboratories

• Drug Synthesis Core- a collaboration between the UNT Health Center and the Washington University to synthesize and pre-clinically assess novel drugs for effectiveness in Alzheimer’s disease.
• Mitochondrial Functional Assessment Core-a multiple capacity core for the assessment of the effectiveness of drugs in improving mitochondrial function.
• Animal Behavioral Assessment Core- an animal core that assesses the effects of aging and Alzheimer’s disease on cognition-related behaviors and evaluated the intervention by diets and drugs.
• Electrophysiology Core- a core that evaluated the effects of aging and diet/drug intervention on function of the hippocampus, the memory area of the brain.
• Alzheimer’s Disease Brain Bank-a facility that solicits, collects, evaluates and stores brains from Alzheimer’s disease persons and cognitively normal controls for distribution to researchers.