Translational Research
- Development of Useful Estrogen-Based Neuroprotectants to identify neuroprotectant compounds, some of which will enter clinical trials (Various Pharmaceutical Companies).
- Texas Higher Education Coordinating Board, Advance Technology Program “Development of Novel Estrogens for Brain Protection”. This grant will complete final preclinical assessments of two novel estrogens for brain protection.
- Discovery of Effective Treatment for and Prevention of Stroke- and Nerve Gas-Related Brain Damage (U.S. Army).
- R01 AG02733 “Brain aging and antioxidant supplementation”
Core Translational Laboratories
- Drug Synthesis Core-a collaboration between the UNTHSC, Washington University and the University of Florida to design, synthesize and pre-clinically assess novel drugs.
- Mitochondrial Functional Assessment Core-a IAADR core, now in operation that can assess mitochondrial function using a Fluorescence Laser Imaging Plate Reader (FLIPR), oxygen electrodes and nitrogen “bombs.”
- Imaging Core - Our imaging core to assess cellular and subcellular localization of molecules. Use is in hypothesis development and in drug screening.
- Brain Bank-A facility/activity for identification, securing, autopsy, characterization, storage and use of well-characterized AD and control brain and other tissues.
