July 3, 2009
  Top Story

Dr. Simpkins

Simpkins’ research goes to clinical trials

Research findings by James Simpkins, PhD, chair of the Pharmacology and Neuroscience, are being put to the test in clinical trials by Parkland Health and Hospital System and UT Southwestern Medical Center.  Simpkins’ research shows that rapid estrogen administration can protect the brain after traumatic injury in animals. These findings are now being tested on human trauma patients in North Texas.

Simpkins’ studies in animals found that rapidly administering a single dose of estrogen, a strong anti-oxidant and an anti-inflammatory drug in stroke increases brain cell survival by up to 65 percent. Estrogens delivered intravenously post injury may have similar effects on people with traumatic brain injury. The animal research has demonstrated that rapid estrogen intervention protects the brain following a traumatic injury, stroke or sudden cardiac arrest.

Simpkins leads a large National Institutes of Health-funded program of research to discover substances that can protect the brain from injury. This is the first major clinical study to emanate from these basic science studies at the Health Science Center.

Parkland’s clinical trials for this research was announced on The Medical News, Expert Click, Medical News Today and the Parkland and UT Southwestern Web sites. A link to the Parkland Web site was also on The33TV.com.

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